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【科学60秒】基因+病毒=疾病
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Crohn's disease is a real pain in the gut. This inflammatory disorder can lead to some serious intestinal difficulties. And ____1____: some 30 different genes enhance susceptibility. But not everyone who has the genes gets Crohn's.
Now scientists find that those with one type of risky gene may also need to ____2____ to trigger the disease. The results appear in the journal Cell.
Doctors have long suspected that some sort of virus might precipitate autoimmune disorders, like lupus or multiple sclerosis. But in the case of Crohn's, researchers ____3____ the connection by accident.
They were studying mice that carry a version of a gene associated with Crohn's. These animals develop gut problems similar to those seen in humans. Then the researchers started keeping the animals in clean cages. Really clean cages, in which the bedding, food, and water are sterilized. And the ____4____ mice, even with the risky gene, stayed healthy. But when the scientists exposed the animals to a common virus, they came down with mouse Crohn's.
The research shows that some illnesses may require a combination of genetic predisposition and infection. ____5____.
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