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【科学60秒】为了下一代:准妈妈,莫饮酒
听力简介:
Pregnant women shouldn’t drink. It’s become gospel, because of the danger of fetal alcohol spectrum disorder. Alcohol can disturb the normal development of a fetus, leading to a lifetime of learning disabilities and social problems. But the percentage of children born with the disorder has remained ___1___, despite the warnings. And not all fetuses of drinking mothers suffer.
Now research with rats has shown why some fetuses are naturally protected. Which could lead to ways to ___2___. The work is in the FASEB Journal. [Laura Sitting et al., "Strain-specific vulnerability to alcohol exposure in utero via hippocampal parent-of-origin expression of deiodinase-III"]
The key is a gene called Dio3, which governs the levels of thyroid hormone in the brain. If mom ___3___ a normal Dio3, no problem. And a male fetus that inherits a problem Dio3 variation from mom but a normal Dio3 from dad should be okay. But alcohol can stop dad’s normal Dio3 gene from working. Now mom’s bad Dio3 allows the brain to ___4___ thyroid hormone, damaging the hippocampus.
The hope is that gene screening could ID women whose fetuses would be at-risk, and that dietary supplements or drugs could block alcohol’s effect. And keep a child from suffering from a parent’s ___5___.
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