返回 【专八新闻系列】第四期2/3

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Imagine antibiotics that would never lose their punch. New research focuses on drugs that(1)__________ simply can't resist. Most antibiotics work by killing pathogens. (2)_____________________________________________________. The rare ones that survive(3)____________, often creating a population that's antibiotic(4)_________.

But what if you could make a drug that(5)__________ bugs harmless, without actually killing them? In that scenario, bacteria might not evolve resistance. And that's what researchers showed in the March 9th issue of Nature Chemical Biology.

The key is communication. In well-trained armies, commanders bark orders, and soldiers signal each other to(6)__________ their positions. The same is true for a lot of infectious bacteria, which(7)_________________ mounting a full assault- complete with toxins- until they are enough of them around.

The scientists designed three different compounds that(8)_________ cell-to-cell signaling in bacteria that cause food poisoning and cholera. And they found that the bugs remained sensitive to drugs, even after 26 generations. They still need to(9)_________ that the bugs that are silenced are in fact less deadly. If so, the new antibiotics would leave bacteria alive, but they'd(10)_____________ be controlled.

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